3. Suplementación con β-hidroxi-β-metil butirato en el envejecimiento

Rodrigo García Madero

Rodrigo García Madero Medicina Interna. Hospital Universitario General de Villalba. Madrid

Palabras clave: Sarcopenia, Masa muscular

Abstract

Existen numerosas revisiones sistemáticas que valoran la efectividad de la suplementación con β-hidroxi-β-metil butirato (HMB) para reducir la sarcopenia en personas mayores y, en la práctica clínica, para atenuar la perdida de músculo y promover la ganancia del mismo. El objetivo de esta revisión es repasar estas revisiones sistemáticas.

There are numerous systematic reviews of HMB and its effectiveness in older persons in mitigating sarcopenia and in clinical practice to attenuate muscle loss or promote muscle gain. The main aim of this review was to conduct an umbrella review of these systematic reviews in which HMB was examined for its effects on older persons and clinical populations.

Recibido: 14 Febrero 2023
Revisión: 20 Febrero 2023
Aceptado: 15 Marzo 2023

Citas

Vol. 7. Nº 10. 2007. Shea BJ, Grimshaw JM, Wells GA, Boers M, Andersson N, Hamel C, et al. Development of AMSTAR: a measurement tool to assess the methodological quality of systematic reviews. BMC Med Res Methodol. Doi: https://doi.org/10.1186/1471-2288-7-10

Vol. 79. Nº 2. Págs. 121-147. 2021. Gielen E, Beckwée D, Delaere A, De Breucker S, Vandewoude M, Bautmans I. Nutritional interventions to improve muscle mass, muscle strength, and physical performance in older people: an umbrella review of systematic reviews and meta-analyses. Nutr Rev. Doi: https://doi.org/10.1093/nutrit/nuaa011

Vol. 33. Nº 1. págs. 71-82. 2009. Baier S, Johannsen D, Abumrad N, Rathmacher JA, Nissen S, Flakoll P. Year-long changes in protein metabolism in elderly men and women supplemented with a nutrition cocktail of beta-hydroxy-beta-methylbutyrate (HMB), L-arginine, and L-lysine. JPEN J Parenter Enteral Nutr. Doi: https://doi.org/10.1177/0148607108322403

Vol. 20. Nº 5. págs. 445-451. 2004. Flakoll P, Sharp R, Baier S, Levenhagen D, Carr C, Nissen S. Effect of beta-hydroxy-beta-methylbutyrate, arginine, and lysine supplementation on strength, functionality, body composition, and protein metabolism in elderly women. Nutrition. Doi: https://doi.org/10.1016/j.nut.2004.01.009

Vol. 35. Nº 1. págs. 18-26. 2016. Deutz NE, Matheson EM, Matarese LE, Luo M, Baggs GE, Nelson JL, et al. Readmission and mortality in malnourished, older, hospitalized adults treated with a specialized oral nutritional supplement: A randomized clinical trial. Clin Nutr. Doi: https://doi.org/10.1016/j.clnu.2015.12.010