Osmotic Demyelination Syndrome in Patients Hospitalized with Hyponatremia

Thomas E MacMillan; Saeha Shin; Joel Topf; Janice L Kwan; Adina Weinerman; Terence Tang; Afsaneh Raissi; Radha Koppula; Fahad Razak; Amol A Verma; Michael Fralick

doi:10.1056/EVIDoa2200215

Osmotic Demyelination Syndrome in Patients Hospitalized with Hyponatremia

NEJM Evid. 2023 Apr;2(4):EVIDoa2200215. doi: 10.1056/EVIDoa2200215. Epub 2023 Mar 23.

Authors

Thomas E MacMillan^{1

2}, Saeha Shin³, Joel Topf⁴, Janice L Kwan^{1

5}, Adina Weinerman^{1

6}, Terence Tang^{1

7}, Afsaneh Raissi³, Radha Koppula³, Fahad Razak^{1

3

8}, Amol A Verma^{1

3

8}, Michael Fralick^{1

5}

Affiliations

¹ Division of General Internal Medicine, Department of Medicine, University of Toronto, Toronto, ON.
² Division of General Internal Medicine, University Health Network, Toronto, ON.
³ Li Ka Shing Knowledge Institute, St. Michael's Hospital, Unity Health Toronto, Toronto, ON.
⁴ Department of Medicine, Oakland University William Beaumont School of Medicine, Rochester, Michigan.
⁵ Division of General Internal Medicine, Sinai Health System, Toronto, ON.
⁶ Division of General Internal Medicine, Sunnybrook Health Sciences Centre, Toronto, ON.
⁷ Institute for Better Health, Trillium Health Partners, Mississauga, ON.
⁸ Institute of Health Policy, Management, and Evaluation, University of Toronto, Toronto, ON.

PMID: 38320046
DOI: 10.1056/EVIDoa2200215

Abstract

Osmotic Demyelination Syndrome and HyponatremiaThe authors estimated the frequency of occurrence of osmotic demyelination syndrome (ODS) after correction of hyponatremia (i.e., serum sodium <130 mmol/l). Among 22,858 patients hospitalized for hyponatremia, there were 12 cases of ODS (0.05%). Correction of the serum sodium occurred in 3632 (17.7%) patients, less than one-half of the ODS cases.

MeSH terms

Demyelinating Diseases*
Humans
Hyponatremia*
Patients
Sodium

Substances

Sodium